SkinCeuticals A.G.E Interrupter Advanced Anti-Wrinkle Cream 48ml

$280.00

A.G.E. Interrupter Advanced Anti-Wrinkle Cream

Target visible signs of skin ageing caused by glycation and collagen depletion.

Recommended For:

• Dry skin

• Normal skin

• Combination skin

• Sensitive skin

• Ageing concerns

Key Benefits

Collagen-boosting formula with niacinamide and Proxylane™ helps improve skin firmness and reduce the look of deep wrinkles and fine lines.
Targets glycation—a leading cause of collagen and elastin degradation—helping restore skin elasticity and reduce sagging.
Smooths creases in high-expression zones like nasolabial folds and marionette lines while enhancing skin tone and radiance.
Strengthens the skin barrier and supports natural hyaluronic acid synthesis for deep hydration and resilience.
Gentle and effective: free of parabens, drying alcohols, and synthetic dyes. Dermatologically tested for mature and sensitive skin types.

Product Overview

A.G.E. Interrupter Advanced is a next-generation anti-wrinkle cream formulated to visibly reduce fine lines, improve skin firmness, and counteract the ageing effects of glycation—a natural process where excess sugars weaken collagen and elastin. This powerful anti-glycation treatment features:

12.6% Proxylane™ – A patented sugar-derived molecule that visibly improves skin density and supports moisture retention.
4.25% Wild Fruit Flavonoids – A potent antioxidant blend of blueberry and pomegranate extracts to combat oxidative stress and glycation.
0.1% Glycyrrhetinic Acid – A soothing, brightening agent that helps restore a healthy glow to dulled, aged skin.
Niacinamide + HEPES – A powerful combination that supports cellular repair, exfoliation, and tone improvement.

Clinically proven to reduce multiple signs of ageing in 12 weeks:

14% reduction in fine lines
11.5% reduction in forehead wrinkles
11% reduction in nasolabial folds
7% reduction in crow’s feet, marionette lines, and glabellar wrinkles

The Science Behind Skin Glycation

Skin glycation is a key driver of accelerated ageing. It occurs when sugar molecules bind to collagen and elastin, forming advanced glycation end-products (A.G.E.s). These structures stiffen and degrade the skin’s support network, leading to:

Fine lines and wrinkles
Loss of skin firmness
A dull, yellowish complexion

A.G.E. Interrupter Advanced directly targets this process, defending against further collagen breakdown while restoring youthful elasticity and radiance.

Glycation DOs & DON’Ts

✅ Do: Use daily SPF and antioxidant serums to protect against environmental accelerators of glycation.
✅ Do: Limit sugar and alcohol intake to reduce internal triggers.
❌ Don’t: Smoke or expose your skin to secondhand smoke, as it worsens oxidative damage and glycation.

Quantity:

A.G.E. Interrupter Advanced Anti-Wrinkle Cream

Target visible signs of skin ageing caused by glycation and collagen depletion.

Recommended For:

• Dry skin

• Normal skin

• Combination skin

• Sensitive skin

• Ageing concerns

Key Benefits

Collagen-boosting formula with niacinamide and Proxylane™ helps improve skin firmness and reduce the look of deep wrinkles and fine lines.
Targets glycation—a leading cause of collagen and elastin degradation—helping restore skin elasticity and reduce sagging.
Smooths creases in high-expression zones like nasolabial folds and marionette lines while enhancing skin tone and radiance.
Strengthens the skin barrier and supports natural hyaluronic acid synthesis for deep hydration and resilience.
Gentle and effective: free of parabens, drying alcohols, and synthetic dyes. Dermatologically tested for mature and sensitive skin types.

Product Overview

12.6% Proxylane™ – A patented sugar-derived molecule that visibly improves skin density and supports moisture retention.
4.25% Wild Fruit Flavonoids – A potent antioxidant blend of blueberry and pomegranate extracts to combat oxidative stress and glycation.
0.1% Glycyrrhetinic Acid – A soothing, brightening agent that helps restore a healthy glow to dulled, aged skin.
Niacinamide + HEPES – A powerful combination that supports cellular repair, exfoliation, and tone improvement.

Clinically proven to reduce multiple signs of ageing in 12 weeks:

14% reduction in fine lines
11.5% reduction in forehead wrinkles
11% reduction in nasolabial folds
7% reduction in crow’s feet, marionette lines, and glabellar wrinkles

The Science Behind Skin Glycation

Fine lines and wrinkles
Loss of skin firmness
A dull, yellowish complexion

A.G.E. Interrupter Advanced directly targets this process, defending against further collagen breakdown while restoring youthful elasticity and radiance.

Glycation DOs & DON’Ts

✅ Do: Use daily SPF and antioxidant serums to protect against environmental accelerators of glycation.
✅ Do: Limit sugar and alcohol intake to reduce internal triggers.
❌ Don’t: Smoke or expose your skin to secondhand smoke, as it worsens oxidative damage and glycation.

DIRECTIONS FOR USE

1. Prep + Dispense

Start by cleansing with SkinCeuticals Glycolic Renewal Foaming Facial Cleanser.

Massage a thin, even layer of A.G.E. Interrupter Advanced anti-wrinkle cream into the skin.

With a pea-sized amount used daily, this cream typically lasts 1–2 months.

Note: Individual results may vary depending on frequency of use and amount applied.

2. Apply + Complete

For best results, apply twice daily.

Morning: After SkinCeuticals C E Ferulic Vitamin C Serum, follow with SkinCeuticals Ultra Facial Defense SPF 50+ Sunscreen.
Evening: If using a retinol product, apply A.G.E. Interrupter Advanced after the retinol step.

INGREDIENTS

Key Ingredients

Paraben Free
Drying Alcohol-Free
Dye-Free

18% Concentrated Proxylane

Proxylane is a sugar/protein hybrid derived from Xylose, a natural sugar. Proxylane helps stimulate collagen production to support skin integrity and correct visible signs of ageing, like wrinkles and laxity.

4.25% Wild Fruit Flavonoids

Plant-derived compounds or flavonoids are beneficial for their antioxidant properties. Flavonoids are also known to help with visible signs of ageing. A combination of blueberry and pomegranate extracts help reduce oxidative stress, which can be linked to A.G.E. formation, and protect against free radical damage.

0.1% Glycyrrhetinic Acid

Glycyrrhetinic acid is one of the components of licorice, known for its ability to help calm skin and minimise sensations of skin sensitivity. It also acts as an antioxidant, helping to counter dull skin tone, which can be linked to A.G.E. accumulation, and is known for its soothing properties.

3% HEPES

Hepes is known for its gentle exfoliating properties, activating natural skin enzymes to promote even skin cell turnover whilst also hydrating skin. It is also known to reduce redness, addressing some acne-prone skin concerns.

1% Niacinamide

Topical niacinamide (AKA vitamin B3) has several antioxidant benefits, also acting as a humectant to help attract and retain moisture within the skin. Niacinamide is a great skincare ingredient for acne-prone or sensitive skin types.

Full Ingredient List

Aqua / Water, Hydroxypropyl Tetrahydropyrantriol, Glycerin, Propylene Glycol, Stearic Acid, Butyrospermum Parkii Butter (Shea Butter), Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES), Palmitic Acid, Pentylene Glycol, Oleyl Alcohol, Arachidyl Alcohol, Myristyl Myristate, Panthenol, Niacinamide, Dimethicone, Isononyl Isononanoate, Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone, Glyceryl Stearate, Candelilla Cera (Candelilla Wax), Behenyl Alcohol, PEG-100 Stearate, Sodium Polyacrylate, Pentaerythrityl Tetraisostearate, 4-t-Butylcyclohexanol, Arachidyl Glucoside, Caprylyl Glycol, Xanthan Gum, Chlorphenesin, Myristic Acid, Caprylic/Capric Triglyceride, Glycyrrhetinic Acid, Parfum (Fragrance), Sorbitol, Vaccinium Myrtillus (Bilberry) Fruit Extract, Potassium Hydroxide, Adenosine, Citric Acid, Punica Granatum (Pomegranate) Fruit Extract, Limonene, Coumarin, Linalool, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate